This project aims at assessing the accumulation of Hg (mercury) by woman living in the Aveiro district, and the potential maternal-fetal transfer during pregnancy. In addition to Hg measurements, related oxidative stress, neurotoxicity and DNA damage effects will be evaluated in both mother and baby tissues and blood. Although some epidemiological studies have already related Hg accumulation in several matrices regarding maternal-fetal transfer, only few studies have regarded this approach in Portugal, and none for the Aveiro district (which includes Estarreja). In addition, only few epidemiological studies have focused on genotoxicity to evaluate Hg exposure in humans. Therefore integrating biomarkers of exposure (Hg measures in maternal and fetal matrices) along with biomarkers of effects (e.g. oxidative stress and DNA damage) will improve the knowledge on the historical problem of Hg contamination in Aveiro region, along with the potential action from local authorities if results show concern to human health.